Janus kinase (JAK) inhibitor.
Pack of 60 Tablets
Xeljanz (Tofacitinib) 5 mg Tablets – What You Need to Know
First JAK Inhibitor for Rheumatoid Arthritis Approved by FDA
Xeljanz (tofacitinib citrate), an oral DMARD (disease-modifying anti-rheumatic drug), was approved by the U.S. Food and Drug Administration (FDA) on November 6, 2012. The drug is intended for the treatment of adults with moderately to severely active rheumatoid arthritis, a disease of the immune system which damages and inflames the joints. This medicine is also used to treat a certain bowel disease (ulcerative colitis) and psoriatic arthritis. Xeljanz can be used as monotherapy (alone), or combined with methotrexate or other non-biologic DMARDs.
“With the approval of Xeljanz, rheumatologists and patients in the US now have an additional treatment option for the management of rheumatoid arthritis that can be taken with or without methotrexate,”. This is an important advancement for the rheumatology community as up to one-third of people with rheumatoid arthritis may not achieve a response with current treatments and a number of patients may not sustain a response. Xeljanz has been cleared in more than 45 countries for use as second-line therapy for moderate-to-severe RA, after failure of one or more DMARDs.
This arthritis medicine should not be used with biologic drugs or powerful immunosuppressants, such as Imuran (azathioprine) or cyclosporine. Before “buy Tofacitinib tablets” (Xeljanz), you need to first get all the tests done under the supervision of a medical practitioner and then start the treatment based on the doctor’s recommendations.
Global Burden of Rheumatoid Arthritis
Rheumatoid arthritis is a common health problem in the global population, affecting more than 350 million people and a leading cause of disability. Out of every 100,000 people, 41 are diagnosed with RA every year. About 1.3 million Americans have RA. Women are 2-3 times more likely than men to have it. Hormones in both genders may play a role in either preventing or triggering it.
RA generally starts between the ages of 30 and 60 in women and somewhat later in life in men. The lifetime risk of developing RA is 3.6 percent for women and 1.7 percent for men. However, RA can strike at any age — even small children can get it.
How does Xelianz work?
Xeljanz is the first oral DMARD approved for rheumatoid arthritis in 10 years. It’s also the first in a new class of medicines known as JAK (Janus kinase) inhibitors. Basically, Xeljanz works by inhibiting the JAK pathway — a signaling pathway inside cells that plays a significant role in inflammation associated with rheumatoid arthritis. Xeljanz Tofacitinib, by blocking the enzymes, reduces the inflammation and other symptoms of rheumatoid arthritis.
How should you use this medicine?
Each white-to-off-white, round, immediate-release, film-coated tablet contains 5 mg of tofacitinib. Regular Xeljanz tablets are typically taken twice a day. The usual dose is 5 milligrams (mg). You can take this medicine with or without food. Be sure to swallow the tablets whole, do not break, chew, or crush them.
Pfizer Xeljanz Price in USA, UK, China, Singapore………..
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